vicissitude

n. unpredictable changes (especially during the course of a lifetime); variability; hardship during a lifetime

n. vicissitude, unpredictable changes

(n.)
Regular change or succession from one thing to another; alternation; mutual succession; interchange.
  

(n.)
Irregular change; revolution; mutation.
  

Noun
1. a variation in circumstances or fortune at different times in your life or in the development of something; "the project was subject to the usual vicissitudes of exploratory research"
(hypernym) variation, fluctuation
2. mutability in life or nature (especially successive alternation from one condition to another)
(hypernym) mutability, mutableness