Venereal Disease Research Laboratory test
The Venereal Disease Research Laboratory test (VDRL) is a nontreponemal serological screening for
syphilis, the monitoring of the response to therapy, the detection of CNS involvement, and as an aid in the diagnosis of congenital syphilis. The basis of the test is that an antibody produced by a patient with syphilis reacts with an extract of ox heart (diphosphatidyl glycerol). It therefore detects
anti-cardiolipin antibodies (IgG, IgM or IgA). Many other conditions can produce false positive results, including some viruses (mononucleosis, hepatitis), drugs, rheumatic fever, rheumatoid arthritis, lupus, and leprosy. The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, where as those that occur in the antiphospholipid antibody syndrome (associated to lupus for example) are beta-2 glycoprotein dependent, and this can be used to tell them apart in an
ELISA assay. This test is very useful as the trend of titres are correlated to disease activity (i.e. falling titres indicate successful treatment). It has a very good sensitivity for syphilis, except in late tertiary form.
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VDRL
Syphilis
VDRL-Test
Sifilide
La sifilide (conosciuta anche come lue, mal francese o morbo celtico) è una malattia infettiva a prevalente trasmissione sessuale. È causata da un batterio (il
Treponema pallidum) dell'Ordine Spirochetales, che si presenta al microscopio come un piccolo filamento a forma di spirale. Il contagio oltre che per via sessuale può estendersi, nella donna gravida con infezione recente, attraverso la placenta al feto che presenta in tal caso un quadro di sifilide connatale con malformazioni che possono interessare: la cute e le mucose, l'apparato scheletrico, l'occhio, il fegato, il rene ed il sistema nervoso centrale.
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Syfilis
Syfilis of lues (verouderd: Franse ziekte) is een seksueel overdraagbare aandoening (
SOA) die wordt veroorzaakt door de
bacterie (
spirocheet)
treponema pallidum. De ziekte komt alleen bij mensen voor. De bacterie treponema cuniculi veroorzaakt bij het
konijn een ziekte die ook syfillis wordt genoemd. Deze bacterie is echter niet besmettelijk voor mensen.
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