Vaccinia virus (VACV or VV) is a large, complex,
enveloped virus belonging to the
poxvirus family. It has a linear, double-stranded
DNA genome approximately 190
kbp in length, and which encodes for approximately 250
genes. The dimensions of the
virion are roughly 360 × 270 × 250
nm. Vaccinia virus is well-known for its role as a
vaccine that eradicated the
smallpox disease, making it the first human disease to be successfully eradicated by mankind. This endeavour was carried out by the
World Health Organization under the Smallpox Eradication Program. Post eradication of smallpox, scientists study Vaccinia virus to use as a tool for delivering genes into biological tissues (
gene therapy and
genetic engineering). Moreover, due to recent concerns about smallpox resurfacing as a possible agent for
bioterrorism, scientists have renewed their interests in studying Vaccinia virus.
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