urokinase

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Urokinase
Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a serine protease . Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive zymogen form of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade which, depending on the physiological environment participate in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
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iMedixDownload this dictionary
Urokinase
Urokinase /uro·ki·nase/ u-plasminogen activator ; an enzyme in the urine of humans and other mammals, elaborated by the parenchymal cells of the [more]Urokinase - Community and Resources


WordNet 2.0 DictionaryDownload this dictionary
urokinase
Noun
1. protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
(synonym) plasminogen activator
(hypernym) protease, peptidase, proteinase, proteolytic enzyme


NCI Dictionary of Cancer Terms Download this dictionary
urokinase
A drug that dissolves blood clots or prevents them from forming.

A Service of the National Cancer Institute.
MEDDIC ENGLISH TO ARABICDownload this dictionary
urokinase
يوروكيناز

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