Tyrosine (abbreviated as Tyr or Y) or 4-hydroxyphenylalanine, is one of the 20
amino acids that are used by
cells to
synthesize proteins. It is a
non-essential amino acid and it is found in large quantities in
casein. The word "tyrosine" is from the
Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist
Justus von Liebig in the protein casein from cheese.As an amino acid, tyrosine has a
phenol side-chain with a
hydroxyl group. Upon the location of the hydroxyl group, there are three structural isomers of Tyr, namely para-Tyr (p-Tyr), meta-Tyr (m-Tyr) and ortho-Tyr (o-Tyr). Only the first isomer (p-Tyr) is produced from L-Phe by the Phe-hydroxylase enzyme. The other two isoforms, m-Tyr and o-Tyr, can be produced as a consequence of
free-radical attack on Phe in states with increased
oxidative stress.
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