rifabutin

Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependend RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant Mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae and M. avium intracellulare.
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[药物]利福布汀。利福霉素的螺旋哌啶衍生物，对结核杆菌的抑菌作用比利福平约强4倍。主要用于分枝杆菌的肺部感染，对利福平耐药的结核杆菌菌株亦有效。1992年在意大利上市

Rifabutin /rif·a·bu·tin/ an antibacterial used for the prevention of disseminated complex disease in patients with advanced HIV infection. [more]Rifabutin - Community and Resources

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an oral drug used as prophylaxis and treatment for tuberculosis and Mycobacterium avium complex (MAC) disease. Side effects may include rash, fever, gastrointestinal distress, liver and kidney toxicity and bone marrow suppression leading to leukopenia.