reverse transcriptase inhibitor

Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that HIV needs to reproduce.
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核苷类逆转录酶抑制剂(Nucleoside Reverse Transcriptase Inhibitors,NRTIs)，是合成HIV的DNA逆转录酶底物脱氧核苷酸的类似物，在体内转化成活性的三磷酸核苷衍生物，与天然的三磷酸脱氧核苷竞争性与HIV逆转录酶(RT)结合，抑制RT的作用，阻碍前病毒的合成。已上市的NRTIs药物有：齐多夫定、去羟肌苷、扎西他滨、司坦夫定、拉米夫定、阿巴卡韦等。
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Noun
1. an antiviral drug that inhibits the action of reverse transcriptase in retroviruses such as HIV
(hypernym) antiviral, antiviral agent, antiviral drug
(hyponym) non-nucleoside reverse transcriptase inhibitor, NNRTI

Inhibitor /in·hib·i·tor/ 1. any substance that interferes with a chemical reaction, growth, or other biologic activity. 2. [more]Reverse transcriptase inhibitor - Community and Resources

a drug that blocks retroviral replication by interfering with the reverse transcriptase enzyme. RTI drugs are not effective after a cell has already been infected. RTI drugs include nucleoside analogs (e.g., AZT, ddI, 3TC, d4T) and non-nucleoside reverse transcriptase inhibitors (e.g., nevirapine, delavirdine).