prime-boost (also heterologous boosting, priming)

in cases when the immune response from a single dose of a vaccine is insufficient to provide effective protection, the same antigen can be administered in two different vectors, successively: The first vector (a live-vector vaccine, for example) iprimesi the immune response with the antigen, and reexposure in the second vector (such as a recombinant subunit vaccine) iboostsi that response; contrasts with the traditional method of homologous boosting in which two or more doses of the same vaccine are given successively.