The auto-loading .22 caliber Remington Nylon 66 rifle was introduced by Remington Arms in 1959, featuring a synthetic stock built from the DuPont material Zytel, a compound similar to Nylon. The largely synthetic construction meant that the Nylon 66 could operate without any added lubricants. This made it very popular in arctic regions, and indeed there have been many reports of indigenous peoples taking large animals, such as moose, with a .22LR fired from a Nylon 66. Some have speculated that the light weight of the gun could potentially cause substandard accuracy in the field, but this does not seem to be a complaint from Nylon 66 shooters.

Os nylons (nome genérico das poliamidas sintéticas) são representados por um sistema de numeração que indica o número de átomos de carbono das cadeias de monômero.