neurofibromatosis type 2

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Neurofibromatosis type II
Neurofibromatosis Type II (or "MISME Syndrome", for "Multiple Inherited SchwannomasMeningiomas, and Ependymomas") is an inherited disease. The main manifestation of the disease is the development of symmetric, non-malignant brain tumours in the region of the cranial nerve VIII, which is the auditory-vestibular nerve that transmits sensory information from the inner ear to the brain. Most people with this condition also experience problems in their eyes. NF II is caused by mutations of the "Merlin" gene which probably influences the form and movement of cells. The principal treatments consist of neurosurgical removal of the tumors and surgical treatment of the eye lesions. There is no therapy for the underlying disorder of cell function caused by the genetic mutation.
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Neurofibromatosis Type 2
Neurofibromatosis type 2 A hereditary condition associated with an increased risk of bilateral acoustic neuromas, other nerve cell tumors and [more]Neurofibromatosis Type 2 - Community and Resources


NCI Dictionary of Cancer Terms Download this dictionary
neurofibromatosis type 2
NF2. A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance. Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow. Also called acoustic neurofibromatosis.

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