Nelarabine is a
chemotherapy drug used in
T-cell acute lymphoblastic leukemia. It was previously known as 506U78. Nelarabine is a
purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of
DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for T-cell
acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens. Complete responses have been achieved with this medication.
See more at Wikipedia.org...
A substance that is being studied in the treatment of cancer. It belongs to the family ofdrugs called antimetabolites. Also called 506U78.
Free Download Now!
