mitotic inhibitor

A mitotic inhibitor is a type of drug derived from natural substances such as plant alkaloids and primarily used in cancer treatment and certain types of cancer research including cytogenetics. Cancer cells are able to grow and eventually metastasize through continuous mitotic division. Generally speaking, mitotic inhibitors prevent cells from undergoing mitosis by disrupting microtubule polymerization, thus preventing cancerous growth. Mitotic inhibitors work by interfering with and halting mitosis (usually during the M phase of the cell cycle), so that the cell will no longer divide. Tubulin, a necessary protein for mitosis to occur, is suppressed by the mitotic inhibitor, preventing mitosis altogether.
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A drug that inhibits cell growth by stopping cell division. Mitotic inhibitors are used as treatments for cancer. Also called antimitotic or antimicrotubule agents and taxanes. Docetaxel and paclitaxel are mitotic inhibitors.