Mechlorethamine also known as chlormethine, mustine, nitrogen mustard and HN2 and sold under the brand name Mustargen, is the prototype
anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of
mustard gas and was derived from
chemical warfare research, in particular a 1943 accident in
Bari,
Italy which exposed civilians and soldiers-- it was noted that white cell counts of exposed patients decreased, suggesting a possible therapy for the cancer
Hodgkin's lymphoma. It belongs to the group of
nitrogen mustard alkylating agents.
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An anticancer drug that belongs to the family of drugs called alkylating agents.
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