magnum opus

n. great work, masterpiece

Noun
1. a great work of art or literature
(hypernym) work of art

Magnum Opus (Latin) The great work; in medieval and modern times an alchemical term for the making of the philosopher's stone and the elixir of life; an achievement which, as with alchemy generally, may be regarded as being accomplished either in the laboratory of human nature among the elements of man's constitution, or in a brick and mortar laboratory with chemicals.

Great work, the major work of one's life

n. งานศิลปะชิ้นเอก, งานศิลปะที่เยี่ยมที่สุด (syn. masterpiece)