Lymphoblasts are immature cells which typically
differentiate to form mature
lymphocytes. Normally lymphoblasts are found in the bone marrow, but in
acute lymphoblastic leukemia (ALL), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood. Although commonly lymphoblast refers to a precursor cell in the maturation of
leukocytes, the usage of this term is sometimes inconsistent. The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells.". Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.
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