Lepirudin (Refludan ®) is an
anticoagulant which functions as a
direct thrombin inhibitor. REFLUDAN was the first direct thrombin inhibitor (DTI) to be approved by the Food and Drug Administration (in 1998) for anticoagulation in patients with
heparin-induced thrombocytopenia (HIT) and associated thromboembolic disease in order to prevent further thromboembolic complications (TECs). It is a recombinant
hirudin, a derivative of the saliva of the medicinal leech Hirudo medicinalis.1 To date, nearly 60,000 patients have been treated with REFLUDAN worldwide.2
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A drug that inhibits blood clotting. It is being studied in cancer treatment.
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