Lamivudine (2',3'-dideoxy-3'-thia
cytidine, commonly called 3TC) is a potent
nucleoside analog reverse transcriptase inhibitor (nRTI).It is marketed by GlaxoSmithKline with the brand names Epivir and Epivir-HBV.Lamivudine has been used for treatment of chronic
hepatitis B at a lower dose than for treatment of
HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.
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