kernicterus

Kernicterus is damage to the brain centers of infants caused by elevated levels of bilirubin. This may be due to several underlying pathologic processes. Newborn babies are often polycythemic, meaning they have too many red blood cells. When they break down the cells, one of the byproducts is bilirubin, which circulates in the blood, and causes jaundice. Alternately, Rh incompatibility between mother and fetus may cause hemolysis of fetal red blood cells, thereby releasing unconjugated bilirubin into the fetal blood. Since the fetal blood brain barrier is not fully formed, some of this released bilirubin enters the brain and interferes with normal neuronal development.
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Kernicterus /ker·nic·ter·us/ [Ger.] a condition with severe neural symptoms, associated with high levels of bilirubin in the blood. ker·nic·ter·us n. [more]Kernicterus - Community and Resources

Noun
1. an abnormal accumulation of bile pigment in the brain and other nerve tissue; causes yellow staining and tissue damage
(hypernym) jaundice, icterus

Disorder due to jaundice in a newborn baby with high blood levels of the pigment bilirubin that is deposited in the brain resulting in damage. The level of bilirubin is monitored in newborns to determine whether treatment is needed to prevent kernicterus. With brain affected, it is also called bilirubin encephalopathy.

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