Keratinocyte Growth Factor
The Keratinocyte Growth Factor (KGF) is a
growth factor present in the
epithelialization-phase of
wound healing. In this phase,
keratinocytes are covering the wound, forming the
epithelium.KGF, also referred to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
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keratinocyte growth factor
KGF. A substance that stimulates the growth of epithelial cells that line the surface of the mouth and intestinal tract. There are several forms of KGF. Recombinant human KGF (rHuKGF) is being studied in the prevention of graft-versus-host disease (GVHD) that may occur after tissue transplantation, and in the treatment of mucositis caused by chemotherapy and radiation therapy. rHuKGF is also called palifermin.
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