Jak
Ják
Janus kinase
Janus kinase (JAK) is a family of intracellular non-receptor
tyrosine kinases, ranging from 120-140
kDa in size, that transduce
cytokine-mediated signals via the
JAK-STAT pathway. Initially discovered in a PCR-based screen of kinases and named ironically as "just another kinase" 1 & 2 (since they were two of a large number of new kinases discovered in the screen) JAK1 and JAK2 were ultimately published as Janus kinase 1 and Janus kinase 2. The name is taken from
Janus, the
Thessalian gatekeeper of heaven worshipped by the
Romans; he is described as having two faces while the JAKs possess two near-identical phosphate-transferring domains. One domain exhibits the kinase activity while the other stabilises the JAK's conformational structure enabling it express that activity.
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jak
Noun
1. immense East Indian fruit resembling breadfruit of; its seeds are commonly roasted
(synonym) jackfruit, jack
(hypernym) edible fruit
(part-holonym) jackfruit, jackfruit tree, Artocarpus heterophyllus
jak (het)
n.
jacket, short coat, blazer; smock, loose protective garment worn over clothing while working
Jak
(n.)
see Ils Jack.
Webster's Revised Unabridged Dictionary (1913), edited by Noah Porter.
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