hybridomas

Hybridoma cells are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, B-cells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells (called hybridomas), being cancer cells, will multiply rapidly and indefinitely and will produce large amounts of the desired antibodies. They have to be selected and subsequently cloned by limiting dilution. Supplemental media containing Interleukin-6 (such as briclone) are essential for this step.
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Un hybridome est une cellule qui provient de l'hybridation entre des cellules lymphoïdes normales de mammifères et des cellules myélomateuses de tumeurs malignes du système immunitaire.
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Hybridom är benämning på celler som har tillverkats för att producera en viss sorts monoklonal antikropp. Ett hybridom består av en B-cell som fuseras med en cancercell från ett myelom.
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‎ وَرَمٌ هَجين‎

وَرَمٌ هَجين