hybridoma

Hybridoma cells are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, B-cells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells (called hybridomas), being cancer cells, will multiply rapidly and indefinitely and will produce large amounts of the desired antibodies. They have to be selected and subsequently cloned by limiting dilution. Supplemental media containing Interleukin-6 (such as briclone) are essential for this step.
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Noun
1. a hybrid cell resulting from the fusion of a lymphocyte and a tumor cell; used to culture a specific monoclonal antibody
(hypernym) somatic cell, vegetative cell

A cell hybrid resulting from the fusion of a cancer cell and a normal lymphocyte (a type of white blood cell). The hybridoma is immortal in the laboratory and makes the same products as its parent cells forever.

A cell that results from the biotech fusion of a bone-marrow tumor cell and a B lymphocyte. Hybridomas replicate (divide) endlessly and can be used to produce specific antibodies in bulk.

hybrid cells made by combining tumor cells and plasma cells; the combination of normal b-lymphocytes and myeloma cells is commonly used in cell-culture expressions systems to produce monoclonal antibodies.