gamma benzene hexachloride

Lindane is a synthetic chemical that was initially developed as an agricultural insecticide and then formulated for medical use due to its antiparasitic efficacy against scabies and lice. Lindane is the gamma isomer of hexachlorocyclohexane (“gamma-HCH”), formerly known as benzene hexachloride or BHC, and more broadly belongs to the organochlorine class of compounds. Its mechanism of action is by interfering with the GABA neurotransmitter function of parasites, specifically by interacting with the GABA_A receptor-chloride channel complex at the picrotoxin binding site. In animal models, lindane has a reported oral LD50 of 88 mg/kg and a dermal LD50 of 1000 mg/kg. In humans, health effects have been described for oral, respiratory and dermal routes of lindane exposure, with varied clinical outcomes depending on the situation, setting and use application.
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