fructose 2,6-bisphosphate

Fructose 2,6-bisphosphate (or fructose 2,6-diphosphate), abbreviated Fru-2,6-P2, is a metabolite which allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Fru-2,6-P2 is synthesized and broken down by the bifunctional enzyme, phosphofructokinase 2/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). The synthesis of Fru-2,6-P2 is performed through the phosphorylation of fructose 6-phosphate using ATP by the PFK-2 portion of the enzyme. The breakdown of Fru-2,6-P2 is catalyzed by dephosphorylation by FBPase-2 to produce Fructose 6-phosphate and Pi.
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