follistatin

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Follistatin
Follistatin is a single chain autocrine glycoprotein found to be ubiquitous within the body of nearly all higher animals, that is the product of a single gene. It was initially isolated from follicular fluid and was identified as a protein fraction that inhibited Follicle-stimulating hormone (FSH) secretion from the anterior pituitary, and so was known as FSH-suppressing protein (FSP). Since then its primary function has been determined to be the binding and bioneutralization agent of members of the TGF-beta superfamily, with primary focus on Activin, a paracrine hormone (TGF-b member) which enhances secretion of FSH in the anterior pituitary.
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Follistatine
Les folliastatines sont des protéines impliquées dans la régulation fine de l’action des facteurs de croissance de la famille du TGFß, modulant notamment l’action des activines et des inhibines.
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Follistatin
Follistatin ist ein autokrines Glykoprotein. Es kommt bei fast allen höher entwickelten Tieren im ganzen Körper vor, wobei sich die höchsten Konzentrationen in den Ovarien und der Haut finden. Es ist Teil der so genannten Inhibin- Activin- Follistatin- Achse. Für seine Produktion wird ein einziges Gen verantwortlich gemacht. das ein direktes Zielgen des Wnt/beta-Catenin-Signalwegs während der Embryonalentwicklung ist.
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Follistatin
Follistatin a gonadal peptide hormone isolated from the ovarian follicular fluid. Suppresses FSH secretion. [more]Follistatin - Community and Resources

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