Follistatin
Follistatin is a single chain autocrine glyco
protein found to be ubiquitous within the body of nearly all higher animals, that is the product of a single gene. It was initially isolated from follicular fluid and was identified as a protein fraction that inhibited
Follicle-stimulating hormone (FSH) secretion from the anterior pituitary, and so was known as FSH-suppressing protein (FSP). Since then its primary function has been determined to be the binding and bioneutralization agent of members of the TGF-beta superfamily, with primary focus on
Activin, a paracrine hormone (TGF-b member) which enhances secretion of FSH in the anterior pituitary.
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Follistatine
Les folliastatines sont des
protéines impliquées dans la régulation fine de l’action des facteurs de croissance de la famille du TGFß, modulant notamment l’action des activines et des inhibines.
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Follistatin
Follistatin