endostatin

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Endostatin
] Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
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Endostatin
En·do·stat·in n. A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors and is under [more]Endostatin - Community and Resources


NCI Dictionary of Cancer Terms Download this dictionary
endostatin
A drug that is being studied for its ability to prevent the growth of new blood vessels into a solid tumor. Endostatin belongs to the family of drugs called angiogenesis inhibitors.

A Service of the National Cancer Institute.

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