A depressant, referred to in slang as a "downer," is a chemical agent that diminishes the function or activity of a specific part of the body. (See also
sedative.) The term is used in particular with regard to the
central nervous system (CNS).
Alcohol (consumed in
alcoholic beverages) is the most obvious example of a depressant. Many depressants acting on the CNS do so by increasing the activity of a particular
neurotransmitter known as
gamma-aminobutyric acid (GABA), although other targets such as the
NMDA receptor, mu-opioid receptor and
CB1 cannabinoid receptor can also be important, depending on which drug is involved.
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SEDATIVO. DEPRIMENTE. SCORAGGIANTE
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