Daclizumab (Zenapax) is a humanized monoclonal
antibody to the IL-2Rα receptor of
T cells. It is used to prevent
rejection in
organ transplantation, especially in
kidney transplants.It is given in multiple doses, the first 1 hour before the transplant operation and 5 further doses given at two week intervals after the transplant. These saturate the receptors and prevent T cell activation and thus prevent formation of
antibodies against the transplant.Like the similar drug
basiliximab, daclizumab reduces the incidence and severity of acute rejection in kidney transplantation without increasing the incidence of
opportunistic infections.
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A monoclonal antibody that is being studied in the treatment of adult T-cellleukemia and in the treatment of cytopenia (low blood cell count). Also called daclizumab.