chronic myelogenous leukemia

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Chronic myelogenous leukemia
Chronic myelogenous leukemia (CML) is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophilseosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Historically, it has been treated with chemotherapyinterferon and bone marrow transplantation, although targeted therapies introduced at the beginning of the 21st century have radically changed the management of CML.
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Chronic myelogenous leukemia
Chronic myelogenous leukemia Also called chronic myelocytic leukemia, malignant disorder that involves abnormal accumulation of white cells in the [more]Chronic myelogenous leukemia - Community and Resources


NCI Dictionary of Cancer Terms Download this dictionary
chronic myelogenous leukemia
[KRAHN-ik mye-eh-LAH-jen-us loo-KEE-mee-a]
CML. A slowly progressing disease in which too many white blood cells (not lymphocytes) are made in the bone marrow. Also called chronic myeloid leukemia or chronic granulocytic leukemia. 

A Service of the National Cancer Institute.

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