Capecitabine (
INN) (
IPA: ) is an orally-administered chemotherapeutic agent used in the treatment of
metastatic breast and
colorectal cancers. Capecitabine is a
prodrug, that is enzymatically converted to
5-fluorouracil in the tumor, where it inhibits
DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil. Capecitabine is marketed under the trade name Xeloda (
Roche).
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A drug that is used in the treatment of cancer. It belongs to the family of drugs called antimetabolites.
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