blast crisis

Chronic myelogenous leukemia (CML) is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Historically, it has been treated with chemotherapy, interferon and bone marrow transplantation, although targeted therapies introduced at the beginning of the 21st century have radically changed the management of CML.
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Blast crisis Stage of chronic myelogenous leukemia where large quantities of immature cells are produced by the marrow and is not responsive to [more]Blast crisis - Community and Resources

The phase of chronic myelogenous leukemia in which more than 30% of the cells in the bone marrow or blood are blast cells (immature, abnormal white blood cells). Tiredness, fever, and an enlarged spleen also occur.