antiphospholipid syndrome

Antiphospholipid syndrome (or antiphospholipid antibody syndrome) (APS) is a disorder of coagulation, which causes blood clots (thrombosis) in both arteries and veins, as well as pregnancy-related complications such as miscarriage, preterm delivery, or severe preeclampsia. The syndrome occurs due to the autoimmune production of antiphospholipid antibodies (aPL). In particular the disease is characterised by anti-cardiolipin and anti-ß2 glycoprotein I antibodies.
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Anticardiolipin antibody Clinical immunology Any of a family of antibodies that recognize an epitope on the cardiolipin molecule; ACA are associated [more]Antiphospholipid syndrome - Community and Resources

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This is due to the presence of antibodies which bind phospholipids. A small proportion of patients have SLE. Recurrent thrombosis occur probably due to inhibition of the phospholipid-dependent coagulation factors.
Clinical features:
*Arterial and venous thrombosis
*Abortions 27% of women who have had more than two abortions have the antiphospholipid syndrome.
Other features:
*Thrombocytopenia
*Chorea, migraine and epilepsy
*valvular heart disease.