amsacrine

Amsacrine is an antineoplastic agent. Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.
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Amsacrine /am·sa·crine/ an antineoplastic that inhibits DNA synthesis; used to treat some forms of leukemia. [more]Amsacrine - Community and Resources

An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.