Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a
polyene antifungal drug, often used
intravenously for systemic
fungal infections. It was originally extracted from
Streptomyces nodosus, a
filamentous bacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the
Orinoco River region of
Venezuela. Its name originates from the chemical's
amphoteric properties. Two amphotericins, Amphotericin A and Amphotericin B are known, but only B is used clinically because it is significantly more active
in vivo. Currently the drug is available as plain Amphotericin B, as cholesteryl sulfate complex, as lipid complex, and as liposomal formulation. The latter formulations have been developed to improve tolerability for the patient but may show considerably different pharmacokinetic characteristics compared to plain Amphotericin B.
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A Anfotericina B é um
antibiótico antifúngico produzido por cultura de
bactérias Streptomyces nodosus. Em geral, atua como fungistático (inibe o crescimento dos fungos, mas não os mata); embora, em concentrações próximas aos limites superiores de tolerância possa ser
fungicida (mata o fungo). É usado para tratar as
micoses há 50 anos, sendo um dos fármacos mais prescritos. Não é útil contra
bactérias.
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