alemtuzumab
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Alemtuzumab
Alemtuzumab (marketed as Campath or Campath-1H) is a
monoclonal antibody
used in the treatment of
chronic lymphocytic leukemia
(CLL) and
T-cell lymphoma
.Alemtuzumab targets
CD52
, a protein present on the surface of mature
lymphocytes
, but not on the
stem cells
from which these lymphocytes were derived. It is used as second line therapy for CLL. It was approved by the
Food and Drug Administration
for patients who have been treated with
alkylating agent
s and who have failed
fludarabine
therapy.
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®
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NCI Dictionary of Cancer Terms
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alemtuzumab
A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells. Also called Campath-1H.
A Service of the
National Cancer Institute
.
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