active site

The active site of an enzyme contains the catalytic and binding sites. The structure and chemical properties of the active site allow the recognition and binding of the substrate.The active site is usually a small pocket at the surface of the enzyme that contains residues responsible for the substrate specificity (charge, hydrophobicity, steric hindrance) and catalytic residues which often act as proton donors or acceptors or are responsible for binding a cofactor such as PLP, TPP or NAD. The active site is also the site of inhibition of enzymes (see Enzyme inhibitor article).
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Noun
1. the part of an enzyme or antibody where the chemical reaction occurs
(hypernym) site, situation
(part-holonym) enzyme

A pocket or crevice on an enzyme molecule that fits reactant molecules like a hand in a glove. The active site lowers the activation energy for reaction.

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