Akathisia, or acathisia, is an unpleasant subjective sensation of "inner" restlessness that manifests itself with an inability to sit still or remain motionless, hence its origin
Ancient Greek α (a), without, not + κάθισις (káthisis), sitting]. Its most common cause is as a
side effect of medications, mainly
neuroleptic antipsychotics especially the
phenothiazines (such as
perphenazine and
chlorpromazine),
thioxanthenes (such as
flupenthixol and
zuclopenthixol) and
butyrophenones (such as
haloperidol (Haldol)),
piperazines (such as
ziprasidone), and rarely,
antidepressants. Akathisia can also, to a lesser extent, be caused by
Parkinson disease-related syndromes.
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