Dexrazoxane hydrochloride (Zinecard®,
Pharmacia) is a
medication used to protect the
heart against the
cardiotoxic side effects of
anthracycline chemotherapy. As a derivative of
EDTA, dexrazoxane
chelates iron, but the precise mechanism by which it protects the heart is not known. It is also used in oncology as an intravenously delivered antidote following extravasation--an adverse event in which chemotherapies containing anthracylines leak out of the blood vessel and necrotize the surrounding tissue.
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