Wobble hypothesis
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Wobble base pair
A wobble
base pair
is a G-U and I-U / I-A / I-C pair fundamental in
RNA
secondary structure
. Its thermodynamic stability is comparable to that of the
Watson-Crick base pair
. Wobble base pairs are critical for the proper translation of the
genetic code
. The genetic code makes up for disparities in the number of
amino acids
(20) for codons (64), by using modified base pairs in the first base of the
anti-codon
. One important modified base is
inosine
which can pair with three bases:
uracil
,
adenine
, and
cytosine
.
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Common Terms in Evolutionary Biology and Genetics Dictionary
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Wobble hypothesis
Hypothesis to explain how one tRNA can recognize two codons. The third base in the anticodon can pair with more than one bases. This is due to the degeneracy of the genetic code which results in more than one triplet codes for some amino acids.
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