Montelukast is a
leukotriene receptor antagonist (LTRA) used for the maintenance treatment of
asthma and to relieve symptoms of seasonal
allergies. It is usually administered orally. Montelukast blocks the action of
leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the
bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute
asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as
theophylline.
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