Santana is the name or partial name of numerous people, places and companies worldwide. It is derived from the contraction of "Santa Ana" or Saint Anne. Other usages include:

• Carlos Santana, Mexican rock musician and guitarist, founder of the band Santana
• Juelz Santana, an American rapper and member of The Diplomats
• Johan Santana, a Venezuelan baseball pitcher, currently with the New York Mets
• Lizette Santana, also known as Lizé, an American recording artist, singer, songwriter, musician, record producer and actress
• Santana Moss, National Football League wide receiver on the Washington Redskins
• Santana Lopez, a fictional character on the TV series Glee
• Santana Martinez, a Native American artist, daughter-in-law and collaborator with Maria Martinez

Sântana (; ; ) is a town in north-western Romania, in the county of Arad. It had 12,936 inhabitants as of 2002. The town is situated in the northern part of the Aradului Plateau, at a 29 km distance from the county capital (Arad). Declared a town in 2003, it administers one village, Caporal Alexa (Erdoskerek).