Ciclosporin (
INN) (
IPA: ) , cyclosporine (
USAN) or cyclosporin (former
BAN), is an
immunosuppressant drug widely used
post-allogeneic organ transplant to reduce the activity of the patient's
immune system and so the risk of organ
rejection. It has been studied in transplants of skin, heart, kidney, lung, pancreas, bone marrow and small intestine. Ciclosporin A, the main form of the drug, is a
cyclic nonribosomal peptide of 11
amino acids (an undecapeptide) produced by the
fungus Tolypocladium inflatum Gams, initially isolated from a
Norwegian soil sample.
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