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Robertsonian translocation

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Robertsonian translocation
Robertsonian translocation (ROB) is a rare form of chromosomal rearrangement that in humans occurs in the five acrocentric chromosome pairs, namely 13, 14, 15, 21, and 22. Other translocations occur but do not lead to a viable fetus. They are named after the American biologist William Rees Brebner Robertson Ph.D. (1881–1941), who first described a Robertsonian translocation in grasshoppers in 1916. They are also called whole-arm translocations or centric-fusion translocations. They are a type of chromosomal translocation.

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Dictionary of Medicine

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Robertsonian translocation
A type of chromosome rearrangement involving all of the essential genetic material of the long arms of two acrocentric chromosomes. The acrocentric chromosomes (those with the centromere near the end so there is only a tiny short arm) are chromosomes 13-15, 21 and 22 in humans. Named after W.R.B. Robertson who in 1916 first described this kind of chromosome rearrangement (in grasshoppers), Robertsonian translocations are also known as whole-arm or centric-fusion translocations. They are relatively common in humans and contribute to the toll of trisomy 13 syndrome and Down syndrome.

Common Terms in Evolutionary Biology and Genetics Dictionary

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Robertsonian translocation
see centric fusion.


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