adj. stubborn, obstinate; resistant to usual treatments; difficult to fuse or process

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Noun
1. lining consisting of material with a high melting point; used to line the inside walls of a furnace
(synonym) furnace lining
(hypernym) lining
(substance-meronym) fireclay

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Adjective
1. resistant to authority or control; "as refractory as a mule"
(similar) uncooperative
2. not responding to treatment; "a stubborn infection"; "a refractory case of acne"
(synonym) stubborn
(similar) intractable
(classification) medicine, medical specialty
3. marked by stubborn resistance to and defiant of authority or guidance; "a recalcitrant teenager"; "everything revolves around a refractory individual genius"
(synonym) recalcitrant
(similar) intractable
4. stubbornly resistant to authority or control; "a fractious animal that would not submit to the harness"; "a refractory child"
(synonym) fractious
(similar) disobedient

(n.)
Refractoriness.
  

(n.)
OPottery) A piece of ware covered with a vaporable flux and placed in a kiln, to communicate a glaze to the other articles.
  

(n.)
A refractory person.
  

(a.)
Resisting ordinary treatment; difficult of fusion, reduction, or the like; -- said especially of metals and the like, which do not readily yield to heat, or to the hammer; as, a refractory ore.
  

(a.)
Obstinate in disobedience; contumacious; stubborn; unmanageable; as, a refractory child; a refractory beast.
  

Not yielding (at least not yielding readily) to treatment.

Anemia (a shortage of red blood cells) unresponsive to treatment.