Sirolimus (
INN) is a relatively new immunosuppressant drug used to prevent
rejection in
organ transplantation, and is especially useful in
kidney transplants. It is also known as rapamycin. Sirolimus is a
macrolide ("-mycin") first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from an island called
Rapa Nui, better known as Easter Island. It is marketed under the trade name Rapamune by
Wyeth.
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