R-flurbiprofen is the single
enantiomer of the
racemate NSAID flurbiprofen. This compound is currently in clinical trials for the treatment of
Alzheimer's disease, and has been assigned the trade name
tarenflurbil. At therapeutic concentrations, this molecule lacks anti-inflammatory activity, and does not inhibit either
cyclooxygenase 1 (COX-1) or
cyclooxygenase 2 (COX-2) enzymes. Only the S-enantiomers of arylpropionic acid
NSAIDS can potently inhibit COX, whereas the R-enantiomers exert almost no COX activity. R-flurbiprofen is inefficiently converted into S-flurbiprofen, with 1.5% of the R-enantiomer undergoing bioinversion to the S-form.
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A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
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