Quinine is a natural white
crystalline alkaloid having
antipyretic (fever-reducing), anti-smallpox,
analgesic (painkilling), and
anti-inflammatory properties and a bitter taste. It is a
stereoisomer of
quinidine.Quinine was the first effective treatment for
malaria caused by
P falciparum, appearing in therapeutics in the 17th century. It remained the antimalarial drug of choice until the 1940s, when other drugs took over. Since then, many effective antimalarials have been introduced, although quinine is still used to treat the disease in certain critical situations. Quinine is available with a prescription in the
United States. Quinine is also used to treat nocturnal leg cramps and
arthritis, and there have been attempts (with limited success) to treat
prion diseases. It was once a popular
heroin adulterant.
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