Proton pump inhibitors (or "PPI"s) are a group of
drugs whose main action is pronounced and long-lasting reduction of
gastric acid production. They are the most potent inhibitors of acid secretion available today. The group followed and has largely superseded another group of
pharmaceuticals with similar effects, but different mode-of-action, called
H2-receptor antagonists. These drugs are among the most widely-selling drugs in the world as a result of their outstanding efficacy and safety. Structurally, the vast majority of these drugs are benzimidazole derivatives; however, promising new research indicates that imidazopyridine derivatives may be a more effective means of treatment.
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