Primary Sclerosing Cholangitis

Primary sclerosing cholangitis (PSC) is a form of cholangitis due to an autoimmune reaction. A cholangitis is an inflammation of the bile ducts of the liver. Primary sclerosing cholangitis leads to cholestasis (blockage of bile transport to the gut). Blockage of the bile duct leads to accumulation of bile, which damages the liver, leading to jaundice and eventually causes liver failure.
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Primary sclerosing cholangitis A chronic disease in which it is believed that the immune system fails to recognize the cells that compose the bile [more]Primary sclerosing cholangitis - Community and Resources

A condition found in association with ulcerative colitis in which the large bile ducts outside the liver become inflamed and obstructed leading to frequent infections and jaundice, causing cirrhosis and sometimes creating the need for liver transplantation.