Position effect

Position effect is the effect on the expression of a gene when its location in a chromosome is changed, often by translocation. This has been well described in Drosophila with respect to eye color and is known as position effect variegation (PEV). The phenotype is well characterised by unstable expression of a gene that results in the red eye coloration. In the mutant flies the eyes typically have a mottled appearance of white and red sectors. These phenotypes are often due to a chromosomal translocation such that the color gene is now close to a region of heterochromatin. The heterochromatin can spread stochastically and switch off the color gene resulting in the white eye sectors.
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Noun
1. (genetics) the effect on the expression of a gene produced by changing its location in a chromosome
(hypernym) consequence, effect, outcome, result, event, issue, upshot
(classification) genetics, genetic science

A difference in phenotype that is dependent on the position of a gene or a group of genes, often caused by heterochromatin nearby. Thus, the change in a gene's location may cause a change in its expression ( a problem that has to be overcome in gene therapy).

B: (Biologi) efek posisi
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